This paper addresses the problem-oriented nature of the author’s 15-year involvement in health communication research. By describing and analyzing the experiences gained from two types of research (HIV/AIDS and communication, and health campaign design and evaluation), the author discusses interdisciplinary characteristics and the need for integrating theory and practice when conducting health communication research. By highlighting the inevitable dilemmas and invaluable re-learning experiences in research processes, the paper ends with discussions of the limitations, opportunities, and ethical reminders for people interested in conducting research in the field of health communication.