Starting with an exposition of the global practice of fact checking, especially the experience of the Taiwan FactCheck Center, this article examines and analyzes the characteristics and types of misinformation and disinformation on COVID-19 as well as the volume of and changes in the information being subjected to fact checking. Related investigations and experience indicate that fact-checking organizations, the news media, and social media platforms have formed a collaborative network constituting the front line in the effort to debunk false information on the pandemic. Fact checking organizations are inherently meant to promote the public good with respect to information; given that the purposes of news and social media are not as fundamentally pure, a certain tension is involved in how fact-checking organizations maintain collaborative relationships with such media enterprises. However, although their purposes and goals differ, collaboration and complementarity are necessary in the face of the infodemic.