Air pollution is gradually becoming the most pressing environmental issue for Taiwanese citizens, government, and news media. Online media outlets disseminate news on air pollution by reposting the content created by online opinion leaders and commenting on the news, and these actions influence how the public approaches and interprets this issue. By conducting an automated content analysis of air pollution news from three major Taiwanese newspapers, the content of PTT posts, users’ response behaviors, and the relationships between these aspects, this research examined the diffusion process of air pollution news in 2017. Particularly, it examined the agenda-setting effects of traditional news media and PTT users’ collective gatekeeping processes as well as their impact on other users’ response behaviors.